< Obstetrics and Gynecology  
        
      Pre-Term Labour
Definition
- Labour occurring between 20 and 37 weeks gestation.
 
Etiology
- 30% idiopathic
 - 30% related to pre-labour rupture of membranes
 - The rest related to a myriad of other factors
 
Management
Antibiotics
- Not-recommended for women in pre-term labour with intact membranes
 
Corticosteroids
- Corticosteroids (betamethasone) should be administered to promote fetal pulmonary development. However, multiple doses should be approached with caution.
 
Tocolysis
- Using atosiban, indomethacin, nifedipine
 - Contraindications to tocolysis include
- Non-reassuring fetal status
 - Dilated cervix >4cm
 - Suspected intrauterine infection
 - Gestational age >34 weeks or <23 weeks
 - Intrauterine fetal death
 - Fetal anomaly incompatible with life
 - Maternal deterioration necessitating delivery
 
 
Pre-Labour Rupture of the Membranes
Definition
- Pre-labor rupture of the membranes (PROM) may occur at pre-term or term dates. PROM poses a significant risk for pre-term labour.
 
Epidemiology
- PROM occurs in less than 30% of pregnancies.
 
Management
- Antibiotics will prolong the latent phase of labour, prevent/treat ascending infection, and reduce the incidence of complications with prematurity.
 
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