Pigmented Villonodular Synovitis

• Rare proliferative disorder affecting joints, tendons, and bursae
• Presnets as a nodule or a diffuse process of the synovium
• Typically monoarticular
• Young and middle-aged adults
• Not clear whether it is a chronic inflammatory process or a neoplastic process
• Work-up MRI, though presence of hemosiderin may overestimate size of lesion
• Primary treatment is surgical resection, although complete resection may be difficult to obtain
• Adjuvant therapy may include radioactive isotopse (Y90) or external beam RT
• For EBRT, University of Florida review recommends 35 Gy in 14-15 fractions

Review

• University of Florida; 2006 PMID 17148989 -- "Pigmented villonodular synovitis." (Mendenhall WM, Am J Clin Oncol. 2006 Dec;29(6):548-50.)