Route 580, or Highway 580, may refer to:
Canada
United Kingdom
United States
I-580
- Interstate 580 (California), a spur connecting the San Francisco Bay Area to the San Joaquin Valley from U.S. Route 101 to Interstate 5
- Interstate 580 (Nevada), a spur connecting Carson City, Nevada to Reno, Nevada (also signed as U.S. Route 395)
- Interstate 580 (Nebraska), a former route and now part of U.S. Route 75 in Omaha, Nebraska
SR 580
Route 580
MD 580
CR 580
PA 580
PR-580
Spur 580
| Preceded by 579 |
Lists of highways 580 |
Succeeded by 581 |
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