 Cytarabine | |
 Daunorubicin | |
| Combination of | |
|---|---|
| Daunorubicin | Anthracycline |
| Cytarabine | Antimetabolite |
| Clinical data | |
| Trade names | Vyxeos |
| Other names | CPX-351 |
| AHFS/Drugs.com | Monograph |
| License data | |
| Pregnancy category |
|
| Routes of administration | Intravenous |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| KEGG | |
Daunorubicin/cytarabine is a fixed-dose combination medication used for the treatment of acute myeloid leukemia.[3][4] It contains the liposomal bound daunorubicin, an anthracycline topoisomerase inhibitor, and cytarabine, a nucleoside metabolic inhibitor.[3]
Medical uses
Daunorubicin/cytarabine is indicated for the treatment of newly-diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC) in people aged one year of age and older.[3][5][6][7][8]
References
- 1 2 "Vyxeos APMDS". Therapeutic Goods Administration (TGA). 15 June 2022. Archived from the original on 18 June 2022. Retrieved 18 June 2022.
- ↑ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
- 1 2 3 4 "Vyxeos (- daunorubicin and cytarabine liposome injection, powder, lyophilized, for suspension". DailyMed. 13 April 2021. Archived from the original on 29 March 2021. Retrieved 18 June 2022.
- ↑ Molica M, Perrone S, Mazzone C, Cesini L, Canichella M, de Fabritiis P (June 2022). "CPX-351: An Old Scheme with a New Formulation in the Treatment of High-Risk AML". Cancers. 14 (12): 2843. doi:10.3390/cancers14122843. PMC 9221356. PMID 35740508.
- ↑ "Vyxeos (cytarabine/daunorubicin liposomal) dosing, indications, interactions, adverse effects, and more". Medscape. Archived from the original on 15 August 2017. Retrieved 19 March 2019.
- ↑ "Vyxeos (cytarabine and daunorubicin) FDA Approval History". Drugs.com. Archived from the original on 11 April 2019. Retrieved 30 December 2018.
- ↑ Chen EC, Fathi AT, Brunner AM (2018). "Reformulating acute myeloid leukemia: liposomal cytarabine and daunorubicin (CPX-351) as an emerging therapy for secondary AML". OncoTargets and Therapy. 11: 3425–3434. doi:10.2147/OTT.S141212. PMC 6003284. PMID 29928134.
- ↑ Cafaro A, Giannini MB, Silimbani P, Cangini D, Masini C, Ghelli Luserna Di Rorà A, et al. (October 2020). "CPX-351 daunorubicin-cytarabine liposome: a novel formulation to treat patients with newly diagnosed secondary acute myeloid leukemia". Minerva Medica. 111 (5): 455–466. doi:10.23736/S0026-4806.20.07017-2. PMID 32955826. S2CID 221842680.
External links
- "Cytarabine mixture with daunorubicin". Drug Information Portal. U.S. National Library of Medicine.
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