First try to find what is going wrong. Run gnome-tweaks from terminal simply typing gnome-tweaks in the terminal. In Tweak will make some changes and see the log in the terminal. If it says
Cannot open dconf database: invalid gvdb header
~/.config/dconf/user* files might have corrupted. Try the following command, it should recreate a new one and allow you to store your settings persistently:
mv ~/.config/dconf/ ~/.config/dconf.bak
Note that you may lose some customization that you may have set on your system as all of them will be reset.
If it does not solve your problem all you have to do is:
mv ~/.config/dconf.bak ~/.config/dconf/
gnome-tweaks
won't impact any of my GUI applications. Whilst I'm no expert (I'm not a big gnome fan), if you're using KDE/Qt based apps as make more sense on my LXQt desktop, gnome or GTK changes have little influence as the changes made impact gnome/GTK based apps. Please add additional info to your question, not everyone reads comments – guiverc Mar 10 '20 at 13:34