I've just migrated from 16.04 to 22.04 on an AMD FX 6 core and Nvidia GTX 750Ti, using Nvidia's driver. Fractional scaling in 16.04 Settings works fine on the same hardware. On my new 22.04 install though, trying to use 1.25 scaling makes the screen looked stretched with ragged dark shades through the view and I have to revert. It may be that Ubuntu has left it to Gnome Tweaks to implement fractional scaling because that works fine for me on 22.04
sudo apt install gnome-tweaks
The same problem looks here to have existed in 20.04
See here for a discussion of why 1.25 scaling is more computationally intensive.