I just installed Ubuntu LTS 22.04. I have guake installed and use the F12 hotkey for opening the Guake window. This usually works fine, except for if the active window is Files (presumably Nautilus, by default now). However, nothing happens apparently in Nautilus -- I can't be sure it's a hotkey set for anything here.
Does Nautilus block the F12 hotkey? If so, how can I turn that off?