The first commands I run when I install Ubuntu 18.04:

gsettings set org.gnome.shell.window-switcher current-workspace-only true
gsettings set org.gnome.shell.app-switcher current-workspace-only true
gsettings set org.gnome.shell.extensions.dash-to-dock isolate-workspaces true
gsettings set org.gnome.desktop.interface gtk-enable-primary-paste true
gsettings set org.gnome.desktop.wm.keybindings switch-to-workspace-1 "['<Alt>1']"
gsettings set org.gnome.desktop.wm.keybindings switch-to-workspace-2 "['<Alt>2']"
gsettings set org.gnome.desktop.wm.keybindings switch-to-workspace-3 "['<Alt>3']"
gsettings set org.gnome.desktop.wm.keybindings switch-to-workspace-4 "['<Alt>4']"
gsettings set org.gnome.desktop.wm.keybindings toggle-maximized "['<Super>x']"
gsettings set org.gnome.desktop.wm.keybindings maximize-vertically "['<Super>v']"
gsettings set org.gnome.desktop.wm.keybindings maximize-horizontally "['<Super>h']"
window buttons on the left, please
gsettings set org.gnome.desktop.wm.preferences button-layout 'close,minimize,maximize'
gsettings set org.gnome.desktop.wm.preferences mouse-button-modifier '<Alt>'
gsettings set org.gnome.desktop.peripherals.mouse natural-scroll false
gsettings set org.gnome.desktop.wm.preferences num-workspaces 4
gsettings set org.gnome.mutter dynamic-workspaces false
gsettings set org.gnome.mutter workspaces-only-on-primary false
Custom kb shortcuts
Super-C
gsettings set org.gnome.settings-daemon.plugins.media-keys.custom-keybinding:/org/gnome/settings-daemon/plugins/media-keys/custom-keybindings/custom0/ binding '<Super>c'
gsettings set org.gnome.settings-daemon.plugins.media-keys.custom-keybinding:/org/gnome/settings-daemon/plugins/media-keys/custom-keybindings/custom0/ command '/snap/bin/gnome-calculator'
gsettings set org.gnome.settings-daemon.plugins.media-keys.custom-keybinding:/org/gnome/settings-daemon/plugins/media-keys/custom-keybindings/custom0/ name "Calculator"
Super-E
gsettings set org.gnome.settings-daemon.plugins.media-keys.custom-keybinding:/org/gnome/settings-daemon/plugins/media-keys/custom-keybindings/custom1/ binding '<Super>e'
gsettings set org.gnome.settings-daemon.plugins.media-keys.custom-keybinding:/org/gnome/settings-daemon/plugins/media-keys/custom-keybindings/custom1/ command '/usr/bin/gedit'
gsettings set org.gnome.settings-daemon.plugins.media-keys.custom-keybinding:/org/gnome/settings-daemon/plugins/media-keys/custom-keybindings/custom1/ name "Text Editor"
Register the custom shortcuts
gsettings set org.gnome.settings-daemon.plugins.media-keys custom-keybindings "['/org/gnome/settings-daemon/plugins/media-keys/custom-keybindings/custom0/','/org/gnome/settings-daemon/plugins/media-keys/custom-keybindings/custom1/']"
fix up some apps
sudo apt install vim-gnome gimp gnome-tweaks clementine
sudo apt remove rhythmbox
if on a laptop:
gsettings set org.gnome.desktop.interface show-battery-percentage true